Electrocardiographic status, changes in blood pressure and serum enzymes in dogs after administration of Vigabatrin

Abstract

Introduction: Epilepsy is a common neurological disorder. The effect of antiepileptic drugs
on cerebral blood flow has long been considered. One of the drugs used in the treatment of
epilepsy is Vigabatrin, which is mainly used in the management of partial seizures and spasms.
This drug is well absorbed after oral administration and 60 to 80% of it is excreted unchanged
in the urine. It can also increase the level of amino butyric acid in the central nervous system
by altering heart functional Heart, heart rate and blood pressure.
Materials & Methods: In this study 12 dogs were randomly used. After cardiac studies
and parasitic infections 5cc of blood samples were taken for serum studies. Vigabatrin
was then administration orally at a dose of 500 mg per kg body weight per day for up
to 7 days. after which an ECG was taken from the right side of the dogs without
anesthesia and stress.
Results: The results were analyzed by one-way analysis of variance (ANOVA). level of
significance of the results was (p≤0.05).
Conclusion: The results showed that the heart rate decreased and the PR and RR intervals
increased.