Synergistic effects of Trans-anethole and L-dopa on serum concentration of adiponectin in rat model of PCOS

Abstract

Introduction: Trans-anethole is a steroidogenic plant derivative. Adiponectin secretion
and dopamine release is lower in patients suffer from polycystic ovary syndrome
(PCOS). In the present study the effects of interaction of trans-anethole and L-dopa were
investigated on serum concentration of adiponectin in PCOS model rats.
Material & methods: Following estradiol valerate- induced PCOS, forty-five PCOS
rats in 9 groups received saline, trans-anethole (50 mg/kg), L-dopa (100 mg/kg), sulpride
(10 mg/kg), SCH23390 hydrochloride (1 mg/kg) or simultaneous injections of these
drugs via intraperitoneal injection. Five intact rats received saline. Blood samples were
collected via tail vein. Serum concentration of adiponectin was determined by ELISA.
Results: Mean serum concentration of adiponectin significantly decreased in PCOs rats
compared to intact group. Adiponectin concentration in PCOS rats receiving
trans- anethole or L-dopa significantly increased compared to PCOS group.
Simultaneous injections SCH23390 hydrochloride and sulpride inhibit the stimulatory
effects of L-dopa on serum concentration of adiponectin via exerting synergistic effects.
Simultaneous injections of trans- anethole and L-dopa synergistically caused a
significant increase in serum concentration of adiponectin compared to PCOS group.
Conclusion: Trans-anethole as a steroidogenic plant derivative, may be an effective
agent for increasing the activity of dopaminergic neurons and controlling the metabolic
complication derived of decreased levels of adiponectin secretion in PCOS.