SCALP MICROBIOME AND HAIR FOLLICLE HEALTH: MICROBIAL INTERACTION ENZYMATIC ACTIVITY AND THERAPEUTIC PERSPECTIVES

Abstract

Diverse bacterial populations that live in different anatomical locations and actively support host homeostasis through interactions with epithelial tissues, immunological pathways, metabolic processes, and barrier functions make up the human microbiome. According to this theory, the skin microbiome is essential for preserving the epithelial barrier, stopping pathogen colonization, and regulating host immune responses. As a result, changes in the functional ability or composition of microorganisms can seriously impair local tissue homeostasis and initiate inflammatory pathways. The present understanding of host-microbe interactions at the epithelial boundary is summarized in this work, which emphasizes how dysbiosis affects the functions of the cutaneous and mucosal barriers. We highlight the primary processes by which changes in microbial communities cause inflammatory diseases by clarifying these immunological and metabolic dynamics. Comprehending these host-microbial interactions reveals possible targets for therapeutic intervention and offers crucial insight into the genesis of inflammatory diseases mediated by the microbiome.